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Process development and scale up

Upstream and downstream process development

Process development and scale-up are essential to obtain a cost-effective commercial product. LFB BIOMANUFACTURING’s services cover adaptation of cell line to serum/protein-free media and / or media optimization for yield improvement.
Upstream (USP) and downstream (DSP) process development are executed in state-of-the-art facilities. LFB BIOMANUFACTURING’s USP technological options include the new ambr®15 advanced microscale bioreactor system for media/feed optimization and single use bioreactors such as wave or disposable stirred tank systems for seed train / scale-up definition.

A proven track record in challenging processes and scale-up

LFB’s in-house scientists and network of experts will facilitate the development of optimum cell culture conditions for each cell line. Our engineering staffs possess a strong experience and a technical knowledge for the selection of optimal chromatography and filtration/purification processes and viral clearance methods.
LFB BIOMANUFACTURING has a proven track records in tackling a number of challenging processes and scale-ups, resulting in successful production of many antibodies and recombinant proteins :

  • Cell culture process development
  • Adaptation to serum-free media
  • Media optimization, yield improvement
  • Media preparation
  • Downstream Process development
  • Manufacturing of non-GMP batches at 50L in pilot area and up to 1000L in the multi-purpose UP1 area