Process development and scale up
UPSTREAM AND DOWNSTREAM PROCESS DEVELOPMENT
Process development and scale-up are essential to obtain a cost-effective commercial product. LFB BIOMANUFACTURING’s services cover adaptation of cell line to serum/protein-free media and / or media optimization for yield improvement.
Upstream (USP) and downstream (DSP) process development are executed in state-of-the-art facilities. LFB BIOMANUFACTURING’s USP technological options include the ambr®15 and ambr®250 advanced microscale bioreactor system for media/feed optimization and single use bioreactors such as wave or disposable stirred tank systems for seed train / scale-up definition.
A PROVEN TRACK RECORD IN CHALLENGING PROCESSES AND SCALE-UP
LFB’s in-house scientists and network of experts will facilitate the development of optimum cell culture conditions for each cell line. Our engineering staffs possess a strong experience and a technical knowledge for the selection of optimal chromatography and filtration/purification processes and viral clearance methods.
LFB BIOMANUFACTURING has a proven track records in tackling a number of challenging processes and scale-ups, resulting in successful production of many antibodies and recombinant proteins :
- Cell culture process development
- Media optimization, yield improvement
- Media preparation
- Downstream Process development
- Manufacturing of non-GMP batches at 50L in pilot area and up to 1000L in one of the 3 multi-purpose workshops. Additional capacities up to 6 times 2000L are being installed.